Here is another good article about Existential Therapy, and the givens: "the tension between life and death, between isolation and connection, between freedom and responsibility, and between meaning and meaningless[ness]."
Facing the Unavoidable Challenges of Life
Some struggles are universal, but that doesn’t mean we are helpless.
www.psychologytoday.com
The Letter to Menoeceus brings up some aspects of the givens in addressing death...and also recommends to not engage in the overindulgence of the profligate (and overindulgence may be a distraction away from properly dealing with the givens). And the Letter to Menoeceus recommends studying the Epicurean philosophy with others of like-mind, which would be a way of both finding meaning and connection.