The main problem posed by the Meno question is a logical one, and so I would say that it has to be met on logical grounds.
In terms of inductive (evidence-based – as opposed to purely deductive) logic, current evidence is indicative of the most fruitful lines of inquiry. Such inquiry may or may not be falsified by future evidence. I’m not sure that the ancients (including the Stoics) had yet grasped the difference between deductive and inductive logic – but I suspect that Epicurus had at least an inkling …